Bone Structure and Metabolism

range from detailed reports of animal experiments and of metabolic balance studies in man to a very stimulating and speculative essay by D. J. Ingle concerning Selye's adaptation hypothesis. The papers in this symposium bring out very clearly that although intensive studies have been carried out in certain spheres concerning the effects of aging, there are many other areas which are virtually untouched. The papers of Pincus and of Samuels, for example, delineate the meticulous and detailed work which they and their coworkers have done in the study of the effects of age upon steroid metabolism. In contrast, Rawson's review of the available data concerning the thyroid in the aging process is valuable in laying bare how very meager are the facts presently at hand and in emphasizing the many important problems in this field which recently developed research techniques have now opened for productive exploitation. This well-edited conference series constitutes an excellent review of current research and thinking in a number of areas of active endocrine investigation.